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I would like to know if it is possible and safe for my amplifier (T600-4 rated at 128 x 4 @ 4 ohms) to run on 1 channel, 4 speakers that are all 4 ohms. I would run the speakers as shown on the wiring diagram in a series/parallel circuit? The speakers are not identical.

Polk Audio db461P –  4”x6”

Overall Frequency Response     71Hz-22kHz
Nominal Impedance     4 ohms
Power Handling (continuous)     50 w
Power Handling (peak)     150 w
Efficiency     91 dB
     

The second set of speakers are; TS-A1604C – 6-1/2”
Overall Frequency Response     29Hz-29kHz
Nominal Impedance     4 ohms
Power Handling (continuous)     50 w
Power Handling (peak)     350 w
Efficiency     90 dB

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i would run 1 per channel. gonna give u the best control and most power.

you can run all 4 off a single channel but you cant get the 4 chan to a 1 chan. only 2,3 or 4